منابع مشابه
Prioritizing Genomic Drug Targets in Pathogens: Application to Mycobacterium tuberculosis
We have developed a software program that weights and integrates specific properties on the genes in a pathogen so that they may be ranked as drug targets. We applied this software to produce three prioritized drug target lists for Mycobacterium tuberculosis, the causative agent of tuberculosis, a disease for which a new drug is desperately needed. Each list is based on an individual criterion....
متن کامل‘Load Points’ and ‘Choke Points’ as Nodes for Prioritizing Drug Targets in Pseudomonas aeruginosa
Biological pathways information has accumulated along with Genomic sequence data. These metabolic pathways help us in understanding network robustness and complex reaction networks. They also provide a framework for improved understanding of microbial physiology and for antimicrobial drug discovery. This article is an attempt to understand the local and global properties of metabolic networks i...
متن کاملA Systematic Assessment of Linking Gene Expression with Genetic Variants for Prioritizing Candidate Targets
Gene expression and disease-associated variants are often used to prioritize candidate genes for target validation. However, the success of these gene features alone or in combination in the discovery of therapeutic targets is uncertain. Here we evaluated the effectiveness of the differential expression (DE), the disease-associated single nucleotide polymorphisms (SNPs) and the combination of t...
متن کاملPrioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have developed a novel method that rapidly screens multiple proteins in parallel using DNA-encoded library technology (ELT). Initial efforts were focused on the efficient discovery of antibacterial leads against 119 targets from Acinetobacter baumann...
متن کاملPrioritizing polio.
www.vi-vi.org We are only US$945 million short of successfully eradicating poliomyelitis: here, a case for why polio eradication should be made a priority worldwide is made – a proposal that is both economically viable and important for health care initiatives in the future. With only 128 cases reported in 2012 (by 6 September 2012) compared with 356 in 2011, we have come closer than ever befor...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2009
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd2933